Necrosis of breast tissue or soft tissues and skin is very unusual after breast augmentation only, it is much more likely in the case of a breast lift where a significant amount of tissue is removed. Necrosis is the result of loss of blood supply, hence oxygen, leading to tissue death. Blood supply is lost when dissection proceeds through tissue containing vessels that supply a given area, and transects them. Since multiple vessels usually supply any given area of breast and skin, sacrifice of a few vessels is usually well tolerated. The use of nicotine in any form (smoking, chewing, gum, patch, etc.), chemotherapy, radiation, corticosteroids, contamination all compromise blood supply and make the sacrifice of even a few vessels a significant risk for breast tissue death.